Qi Zhang Lab

Gail EH, Healy E, Flanigan SF, Jones N, Ng XH, Uckelmann M, Levina V, Zhang Q#, Davidovich C#.  Inseparable RNA binding and chromatin modification activities of a nucleosome-interacting surface in EZH2. Nature Genetics. 2024 doi:10.1038/s41588-024-01740-8

Healy E*, Zhang Q*, Gail EH, Agius SC, Sun G, Bullen M, Pandey V, Das PP, Polo JM, Davidovich C. The apparent loss of PRC2 chromatin occupancy as an artefact of RNA depletion. Cell Rep. 2024 doi: 10.1016/j.celrep.2024.113858

Deevy O, Monger C, Matra F, Tuck E, Conway E, Rodighiero S, Zhang Q, Davidovich C, Pasini D, Bracken AP. Dominant negative and directional dysregulation of Polycomb function in EZH2-mutant human growth disorders. bioRxiv. 2023 doi: 10.1101/2023.06.01.543208

Uckelmann M, Levina V, Taveneau C, Ng XH, Pandey V, Zhang Q, Flanigan S, Li M, Das PP, de Marco A, Davidovich C. Dynamic PRC1-CBX8 stabilizes a porous structure of chromatin condensates. bioRxiv. 2023 doi: 10.1101/2023.05.08.539931

Barszczyk A, Bandura J, Zhang Q, Wang H, Deurloo M, Ahmed Y, Dong A, Meister P, Lee J, Sun HS, Tong Y, Feng ZP. Caltubin regulates microtubule stability via Ca2+-dependent mechanisms favouring neurite regrowth. bioRxiv. 2023 doi: 10.1101/2023.01.23.525163

Zhang Q*, Agius SC*, Flanigan SF, Uckelmann M, Levina L, Owen BM, Davidovich C. PALI1 facilitates DNA and nucleosome binding by PRC2 and triggers an allosteric activation of catalysis. Nature Communications. 2021. doi: 10.1038/s41467-021-24866-3. PMID: 34321472

Davidovich C, Zhang Q. Allosteric regulation of histone lysine methyltransferases: from context-specific regulation to selective drugs. Biochem Soc Trans. 2021. doi: 10.1042/BST20200238. PMID: 33769454

Zhang Q*, McKenzie NJ*, Warneford-Thomson R*, Gail EH, Flanigan FF, Owen BM, Lauman R, Levina V, Garcia BA, Schittenhelm RB, Bonasio R, Davidovich C. RNA exploits an exposed regulatory site to inhibit the enzymatic activity of PRC2. Nature Struct Mol Biol. 2019. doi: 10.1038/s41594-019-0197-y. PMID: 30833789

Paudel P*, Zhang Q*, Leung C*, Greenberg HC, Guo Y, Chern YH, Dong A, Li Y, Vedadi M, Zhuang Z, Tong Y. Crystal structure and activity-based labeling reveal the mechanisms for linkage-specific substrate recognition by deubiquitinase USP9X. PNAS. 2019. doi: 10.1073/pnas.1815027116. PMID: 30914461